Thrombolysis in Patients With Large‐Vessel Occlusion Directly Admitted or Transferred to a Thrombectomy Center: A Population‐Based Study

BACKGROUND Our goal is to evaluate whether the administration of thrombolytic treatment has varying effects on clinical and radiological outcomes in patients with large‐vessel occlusion stroke, based type stroke center where was given (thrombectomy‐capable versus local center). METHODS We included an acute ischemic who were directly admitted thrombectomy‐capable centers treated endovascular thrombectomy, or transferred from as thrombectomy candidates, Catalonia, Spain, between 2017 2021. The primary outcome shift analysis modified Rankin scale score at 90 days. Secondary death days rate parenchymal hemorrhage successful reperfusion. Inverse‐probability weighting clustered used estimate effects. RESULTS 2268 centers, whom 975 (49%) thrombolysis, 938 580 (66%) thrombolysis 616 (67%) thrombectomy. Mean age 72 (SD ±13) years, median National Institute Health Stroke Scale 17 (interquartile range, 12–21), 1363 women (48%). Patients intravenous younger, had shorter time onset first image, higher Alberta Program Early Computed Tomography Score, lower rates wake‐up atrial fibrillation, anticoagulation intake. better functional days, no difference (adjusted common odds ratio [acOR], 1.50 [95% CI, 1.24–1.81]) (acOR, 1.44 1.04–2.01]). rate, hematoma, similar reperfusion, according ( P interaction >0.1). CONCLUSION Administration a intention associated degrees disability, hematoma both centers.